In 1973, three San Antonio physicians, working with the Bexar County Medical Society, became the charter trustees of a new locally-owned and locally-operated, nonprofit blood bank, South Texas Regional Blood Bank (STRBB). The company grew rapidly from its modest beginnings. In 1991, the blood bank added the National Marrow Donor Program registry and also began collecting umbilical cord blood. In 1994, it moved to its present facility on IH-10 West and changed its name to the South Texas Blood & Tissue Center to reflect its newly expanded mission into tissue collection. In 1996, the Center became the first North American blood and tissue center to achieve ISO 9000 Registration, a prestigious international standards certification. Continuing to diversify, the blood bank achieved other milestones by adding The Blood & Tissue Center Foundation (2002), and the Texas Cord Blood Bank (2003), as well as creating a nonprofit testing affiliate, QualTex Laboratories.

In 2012, the company saw the need to reorganize its structure. The new company BioBridge Global is structured to grow and diversify services. Our strategic plan will use our company's strengths and building partnerships with others. BioBridge Global has over 700 employees that provide services across the globe.  South Texas Blood & Tissue operates five donor rooms in San Antonio, and has donation sites in New Braunfels and Victoria. QualTex Laboratories has staff on the west coast as well as a satellite center in Norcross, Georgia. GenCure collects and processes tissue components, receives umbilical cord blood from hospitals across Texas and operates an on-site peripheral blood stem cell collection center.

Through adaptation and growth, BBG has positioned itself in the industry to meet its fundamental mission of providing products and services that positively impact the health care needs of the communities we serve.