Tissue regeneration researchers awarded two major grants

December 10, 2018
tissue-regeneration-blog

Scientists at Cedars-Sinai Medical Center have received two grants to help continue groundbreaking research on tissue regeneration.

Their method injects microbubbles with a bone-inducing gene into damaged tissues. Those areas are then treated with ultrasound waves, which mediates the delivery of the DNA into stem cells. Parts of the DNA become incorporated into the stem cells, activating the patient’s own stem cells to heal the injury.

“This type of gene delivery has the advantage of being targeted and safe, compared to using viral-based gene therapy,” said Scott Jones, vice president of scientific affairs at BioBridge Global. “This type of treatment is also nice because it’s noninvasive and uses the patient’s own cells, plus it doesn’t require growing stem cells outside the body.”

These researchers have shown in two different studies in a mini-pig model that this type of treatment could regrow a shinbone in eight weeks and heal a ligament tear within a knee joint. The therapy could be used to regenerate damage from severe traumas or battlefield wounds.

The researchers received $5 million grant from the Department of Defense to advance the technique to clinical trials. A $2.8 million grant from the National Institutes of Health will be used to develop ultrasound machines suited to the process.

The material that appears on this blog is for informational purposes only.  In many instances, we are sharing information first reported elsewhere. Posting here does not imply any endorsement of specific research. When available, links to the original research content are available within the blog post.  We are not responsible if information we make available on this site is not accurate, complete or current.


More from our blog:

QualTex Laboratories wins top poster award at national conference for the first time

Five things you should know about BioBridge Global

Wounds heal themselves with reprogrammed skin cells