Wounds heal themselves with reprogrammed skin cells

October 29, 2018

The most common surgical procedures used in wound healing are skin grafts and local flap surgery, where the surrounding skin repairs the epidermis of the open wound.

However, the interventions come with their risks and aren’t always successful, highlighting the need for a more effective, non-surgical intervention using stem cells.

Researchers at the Salk Institute discovered a potential pathway to reprogram mesenchymal cells already in the open wound into new skin cells.

The new technique involved treating skin ulcers on mice. Four reprogramming factors (proteins from adult stem cells) were determined to have excellent wound-healing capacity because they were most likely to develop into basal keratinocytes (skin cells in the innermost layer of the epidermis). Healthy skin covered the ulcers within 18 days. The regrown cells behaved like healthy skin cells up to six months later.

The potential of the study goes beyond ulcers, including new treatments for skin diseases, skin cancers, and burns in less time and with fewer complications.

GenCure works with researchers and organizations developing innovative cellular therapy treatments for a variety of disorders.

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